Take the free Cardiovascular Risk Estimator. Answer 25 evidence-based questions about your lifestyle, history, and symptoms to receive a personalized heart health risk score with a category-by-category breakdown and action plan. Cardiovascular disease remains the leading cause of death in the United States and most of the developed world. The encouraging reality is that the majority of cardiovascular disease is preventable - research shows that lifestyle factors account for the vast majority of modifiable risk, and that meaningful changes at any age can substantially reduce the probability of a heart attack or stroke.